Publications | COoL Lab

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Publications in chronological order

2020-2025

Sudha Rajamani, Cole Mathis, Silke Asche, David Boulesteix, Celia Blanco, Omer Markovitch, Alexandre Champagne-Ruel, Carla Bautista, Zhen Peng: Better origin(s) of life research through collaboration across disciplines, 2026, https://doi.org/10.1016/j.xcrp.2026.103220
Udita Bandyopadhyay, Souradeep Das, Sahil Sunil Mulewar, Tejashwini R, and Sudha Rajamani: Amino Acids as Molecular Linchpins in the Fundamental Prebiotic Processes of RNA Copying and Vesicle Formation, 2026, https://doi.org/10.1177/15311074261434675
Gauri M. Patki, Vanthanaa Sridhar, Sudha Rajamani: Characterizing Mixed Single-Chain Amphiphile-Based Coacervates as a Robust Protocell System, 2025, https://doi.org/10.1002/cbic.202500437
Souradeep Das, Ruchira Pal, Dr. Sudha Rajamani: Dynamical interactions among protocell populations: Implications for membrane-mediated chemical evolution, 2025, https://doi.org/10.1098/rstb.2025.0104
Kshitij Deshpande, Nishant Nitinidhi Kulshreshtha, Sahil Sunil Mulewar, Dr. Sudha Rajamani: Nucleotide-Protocell Interactions: A Reciprocal Relationship in Prebiotically Pertinent Environments, ChemSystemsChem, 2024, https://doi.org/10.1002/syst.202300031
Souradeep Das, Gauri M Patki, Vanthanaa Sridhar, Sahil Sunil Mulewar, Raya Roy, Udita Bandyopadhyay, Nishant Nitinidhi Kulshreshtha, Sudha Rajamani: Compartmentalization as a ubiquitous feature of life: from origins of life to biomimetics, The European Physical Journal Special Topics, 2024.
Anupam A. Sawant, Sneha Tripathi, Sanjeev Galande, Sudha Rajamani: A Prebiotic Genetic Nucleotide as an Early Darwinian Ancestor for Pre-RNA Evolution, ACS Omega, 2024.

Gauri M. Patki, Sudha Rajamani: Nonenzymatic RNA replication in a mixture of ‘spent’ nucleotides, FEBS letters, 2023.
Shikha Dagar, Susovan Sarkar, Sudha Rajamani: Nonenzymatic Template-Directed Primer Extension Using 2'-3' Cyclic Nucleotides Under Wet-Dry Cycles, Discover life, 2023, 10.1007/s11084-023-09636-z

Anuraag Aithal, Shikha Dagar, and Sudha RajamaniMetals in Prebiotic Catalysis: A Possible Evolutionary Pathway for the Emergence of Metalloproteins. ACS Omega, 2023.

Rajamani, S., Biondi, E. Mist and replication. Nature Physics, 2022.

Joshi, M.P., Uday A., Rajamani, S. Elucidating N-acyl amino acids as a model protoamphiphilic system. Commun Chem, 2022.

Sarkar, S., Dagar, S., Lahiri,K., Rajamani, S. pH-responsive self-assembled compartments as tuneable model protocellular membrane systems. ChemBioChem, 2022.

Dagar, S., Sarkar, S. and Rajamani, S. Porphyrin in prebiotic catalysis: Ascertaining a route for the emergence of early metalloporphyrins. ChemBioChem, 2022.

Joshi, M.P., Steller, L.; Van Kranendonk, M.J.; Rajamani, S. Influence of Metal Ions on Model Protoamphiphilic Vesicular Systems: Insights from Laboratory and Analogue Studies. Life, 2021.

Sarkar, S. Dagar, S., Rajamani, S. Influence of Wet-dry Cycling on the Self-Assembly and Physicochemical Properties of Model Protocellular Membrane Systems. ChemSystemsChem, 2021.

Joshi, M. P., Sawant, A. A., Rajamani, S. Spontaneous emergence of membrane-forming protoamphiphiles from a lipid-amino acid mixture under wet-dry cycles. Chem. Sci, 2021.

Sarkar, S., Das, S., Dagar, S., Joshi, M. P., Mungi, C. V., Sawant, A. A., Patki, G.M. & Rajamani, S. Prebiological Membranes and Their Role in the Emergence of Early Cellular Life. J Membrane Biol, 2020.

Dagar, S., Sarkar, S., & Rajamani, S. Geochemical influences on nonenzymatic oligomerization of prebiotically relevant cyclic nucleotides. RNA, 2020.

Sarkar, S., Dagar, S., Verma, A., & Rajamani, S. Compositional heterogeneity confers selective advantage to model protocellular membranes during the origins of cellular life. Scientific reports, 2020.

Bapat, N. V., Paithankar, H., Chugh, J., & Rajamani, S. NMR analysis of nucleotide π-stacking in prebiotically relevant crowded environment. Communications Chemistry, 2020.

Roy, S., Bapat, N. V., Derr, J., Rajamani, S., & Sengupta, S. Emergence of ribozyme and tRNA-like structures from mineral-rich muddy pools on prebiotic earth. Journal of Theoretical Biology, 2020

Mungi, C. V., Bapat, N. V., Hongo, Y., & Rajamani, S. Formation of Abasic Oligomers in Nonenzymatic Polymerization of Canonical Nucleotides, Life 2019.

Pandey, S., Clarke, J., Nema, P., Bonaccorsi, R., Som, S., Sharma, M., ... & Vaishampayan, P. Ladakh: diverse, high-altitude extreme environments for off-earth analogue and astrobiology research. International Journal of Astrobiology, 2019.

Bapat, N. V., & Rajamani, S. Templated replication (or lack thereof) under prebiotically pertinent conditions. Scientific reports, 2018.

Joshi M. P., Samanta A., Tripathy G. R. and Rajamani S. Formation and Stability of Prebiotically Relevant Vesicular Systems in Terrestrial Geothermal Environments. Life, 2017.

Mungi, C. V, Singh, S.K., Chugh, J., and Rajamani, S. Synthesis of barbituric acid containing nucleotides and their implications for the origin of primitive informational polymers. Phys. Chem. Chem. Phys., 2016.

Xulvi-Brunet, R., Campbell, G.W., Rajamani, S., Jiménez, J.I., and Chen, I.A. Computational analysis of fitness landscapes and evolutionary networks from in vitro evolution experiments. Methods, 2016.

Bapat, N. V, and Rajamani, S. Effect of Co-solutes on Template-Directed Nonenzymatic Replication of Nucleic Acids. J. Mol. Evol., 2015.

Mungi, C. V, and Rajamani, S. Characterization of RNA-Like Oligomers from Lipid-Assisted Nonenzymatic Synthesis: Implications for Origin of Informational Molecules on Early Earth. Life, 2015.

Scharf Caleb, Virgo Nathaniel, Cleaves H. James II, Aono Masashi, Aubert-Kato Nathanael, Aydinoglu Arsev, Barahona Ana, Barge Laura M., Benner Steven A., Biehl Martin, Brasser Ramon, Butch Christopher J., Chandru Kuhan, Cronin Leroy, Danielache Sebastian, Fischer Jakob, Hernlund John, Hut Piet, Ikegami Takashi, Kimura Jun, Kobayashi Kensei, Mariscal Carlos, McGlynn Shawn, Menard Brice, Packard Norman, Pascal Robert, Pereto Juli, Rajamani Sudha, Sinapayen Lana, Smith Eric, Switzer Christopher, Takai Ken, Tian Feng, Ueno Yuichiro, Voytek Mary, Witkowski Olaf, and Yabuta Hikaru. A Strategy for Origins of Life Research. Astrobiology (2015).

Pre-COoL Lab

Ivica, N. A., Obermayer, B., Campbell, G. W., Rajamani, S., Gerland, U., & Chen, I. A. (2013). The paradox of dual roles in the RNA world: resolving the conflict between stable folding and templating ability. Journal of molecular evolution, 77(3), 55-63.
Derr, J., Manapat, M. L., Rajamani, S., Leu, K., Xulvi-Brunet, R., Joseph, I., ... & Chen, I. A. (2012). Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences. Nucleic acids research, 40(10), 4711-4722.
Leu, K., Obermayer, B., Rajamani, S., Gerland, U., & Chen, I. A. (2011). The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. Nucleic acids research, 39(18), 8135-8147.
Rajamani, S., Ichida, J. K., Antal, T., Treco, D. A., Leu, K., Nowak, M. A., ... & Chen, I. A. (2010). Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. Journal of the American Chemical Society, 132(16), 5880-5885.
Rajamani, S., Vlassov, A., Benner, S., Coombs, A., Olasagasti, F., & Deamer, D. (2008). Lipid-assisted synthesis of RNA-like polymers from mononucleotides. Origins of Life and Evolution of Biospheres, 38(1), 57-74.
Zepik, H.H., Rajamani, S., Maurel, M.-C., and Deamer, D. (2007). Oligomerization of thioglutamic acid: encapsulated reactions and lipid catalysis. Orig. Life Evol. Biosph. 37, 495–505.
Deamer, D., Singaram, S., Rajamani, S., Kompanichenko, V., and Guggenheim, S. (2006). Self-assembly processes in the prebiotic environment. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 361, 1809–1818.
Li, J., Zhu, M., Rajamani, S., Uversky, V.N., and Fink, A.L. (2004). Rifampicin Inhibits α-Synuclein Fibrillation and Disaggregates Fibrils. Chem. Biol. 11, 1513–1521.
Sudha, R., Anantharaman, L., Sivaram, M.V.S., Mirsamadi, N., Choudhury, D., Lohiya, N.K., Gupta, R.B., and Roy, R.P. (2004). Linkage of Interactions in Sickle Hemoglobin Fiber Assembly: INHIBITORY EFFECT EMANATING FROM MUTATIONS IN THE AB REGION OF THE α-CHAIN IS ANNULLED BY A MUTATION AT ITS EF CORNER . J. Biol. Chem. 279, 20018–20027.
Sivaram, M.V.S., Sudha, R., and Roy, R.P. (2001). A Role for the α113 (GH1) Amino Acid Residue in the Polymerization of Sickle Hemoglobin: EVALUATION OF ITS INHIBITORY STRENGTH AND INTERACTION LINKAGE WITH TWO FIBER CONTACT SITES (α16/23) LOCATED IN THE AB REGION OF THE α-CHAIN . J. Biol. Chem. 276, 18209–18215.

Book Chapters

Xulvi-Brunet, R., Campbell, G.W., Rajamani, S., Jiménez, J.I., and Chen, I.A. (2016). Quantitative Analysis of Synthesized Nucleic Acid Pools BT - Nonlinear Dynamics in Biological Systems. J. Carballido-Landeira, and B. Escribano, eds. (Cham: Springer International Publishing), pp. 19–41.

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